The suspense adventure film "Miss Holmes: The Lost Marquis" produced by Legendary Pictures and adapted from Nancy springer’s "Enola Holmes" series in mystery novel has recently released the world’s first preview, which is scheduled to go online on September 23rd and is expected to be introduced in China. From the perspective of Sherlock Holmes’ little-known sister Enola Holmes, the preview brings us into a brand-new adventure story about the Sherlock Holmes family. At the same time as the preview, the first official poster was exposed, and all the star lineups and shapes of "Little 11" Millie Bobby Brown, "Big Super" Henry Cavill, Sam Claflin and helena bonham carter were exposed, which made romance and suspense coexist. Miss Holmes: The Lost Marquis (tentative translation) is directed by Emmy, BAFTA and Golden Globe winner Harry Bradbeer (Life in London, Kill Eve), with BAFTA and Tony Award winner Jack Thorne (Harry Potter and the Cursed Child, Aeronauts) participating in the screenplay, and tells the story of Sherlock Holmes’ sister Enola.Exposed a dangerous plot around the mysterious young Lord, and gradually grew into a super detective who can be independent.

This "sister" is not generally smarter than Sherlock’s "Sister Holmes" has come.

In the preview, Millie Bobby Brown plays Enola Holmes as a woman with extraordinary charm. Under the "unusual" teaching of her mother, she is athletic and good at archery, fencing, boxing and many other sports; She doesn’t follow the rules and has her own unique opinions and keen thinking; She is always ahead of Sherlock Holmes in reasoning games; She is clever and clever, and she is not inferior to her two "world-famous" brothers Sherlock Holmes and mycroft holmes. When she found out that her mother was missing, she cleverly deceived her two brothers and made a bold decision to "escape" to London to find out the truth about her disappearance. On the way to adventure, she encountered many obstacles, such as jumping off the train, being hunted down, fighting with others, and being exploded. Her mother’s past teaching played a role at the critical moment, which made her feel close to danger all the way. What is the truth about mother’s disappearance? What kind of difficulties will Enola encounter after London? All kinds of suspense make people look forward to the feature film.

At the same time, the posters exposed at the same time are both romantic and suspenseful, with bright colors and clip art design. Enola Holmes in a red dress in the blooming flowers and the people in the magnifying glass behind him look different and make people explore. Enola, the "Sister Holmes", has a firm eye and calmly faces the unknown risks ahead. My eldest brother Mycroft seems to be planning with a frown, while my second brother Shylock is calm and confident. The film’s rich retro British style leads us back to the 19th century, and also shows her wisdom and courage to break through the shackles of women’s secularism in society at that time through the perspective of Enola Holmes. Enola is different from the traditional 19th century lady. She is independent, confident, intelligent and agile, has her own views on the world, and is willing to seek the truth and even change the world by her own strength. She injected fresh vitality into Sherlock Holmes, the greatest detective in the world, and his outstanding family, showing the rise of female power.

The "Strongest" Detective Brothers and Sisters in the "Little Eleven" and "Super Super" Groups Rebuild Top Teams in Hollywood.

Miss Holmes: The Lost Marquis (tentative translation) is extremely eye-catching in the cast. The film is starring Millie Bobby Brown, who is widely loved by the audience because of Godzilla 2: The King of Monsters and Strange Tales. The world-famous detective Sherlock Holmes is played by Henry Cavill, an actor who is twice as popular because of Superman: The Man of Steel. How will he play Sherlock Holmes? Mycroft holmes, the eldest brother, is played by the actor Sam Claflin (masterpiece: The Hunger Games series and Me Before You), and helena bonham carter (masterpiece: The King’s Speech, Wings of Doves and Harry Potter series), who was nominated for the Oscar twice, plays Eudora, the most mysterious mother in the Sherlock Holmes family. Adeel akhtar (masterpiece: A Serious Disease, Murder Mystery Cloud), fiona shaw (masterpiece: Kill Eve, Harry Potter series movies), frances de la tour (masterpiece: Dark Forest, Harry Potter series movies), Louis partridge.(Masterpiece: Netflix version of medici family), burn gorman (Masterpiece: Pacific Rim), Susan Wokoma (Masterpiece: Crazy Monster) and other powerful actors also joined Miss Holmes: The Lost Marquis (tentative translation).

The production team of Miss Holmes: The Lost Marquis is even more powerful, with Legendary Pictures’s Mary Parent, Alex Garcia, Ali Mendes and Peggy Brown, who starred in Millie Bobby Brown and PCMA management production company, as producers. The executive producers are Joshua Grad, Michael Derel and Harry Bradbeer from Legendary Pictures. There are also photographers Gilles Natkins (Go through Fire and Water, Colette) who have been nominated by BAFTA, production designer Michael Karin (The Duchess and Colette) who have been nominated by Oscar, editor Adam bosman (The Crown for Netflix) and fashion designer Soletta Boyle who has been nominated by three Oscars.

A brand-new suspense adventure film "Miss Holmes: The Lost Marquis" (tentative translation) is produced by Legendary Pictures, and it is scheduled to go online on September 23rd. It is expected to be introduced in China, and the adventure belonging to Holmes’ sister is about to begin!

　　CCTV News:On April 18th, the State Council held a press conference on the development of industry and informatization in the first quarter of 2024. Shan Zhongde, Vice Minister of the Ministry of Industry and Information Technology, introduced at the meeting that major industrial provinces, cities and key industries maintained steady growth in the first quarter. The industrial added value of 28 of the 31 provinces increased year-on-year, and the growth rate of 9 major industrial provinces such as Jiangsu, Shandong, Zhejiang, Fujian and Hubei was higher than the national average. Among the 50 major industrial cities, Shenzhen, Suzhou, Hefei, Nantong, Taizhou and Dongguan have achieved double-digit growth, and major industrial provinces and cities have played a leading role. Key industries are running smoothly and well. Among the 41 major industrial sectors, the added value of 37 industries, such as electronics and automobiles, maintained a year-on-year growth, with an increase of 22 percentage points over last year. The equipment manufacturing industry continued to grow rapidly. In the first quarter, the added value increased by 7.6% year-on-year, which boosted the growth of industries above designated size by 2.4 percentage points, giving play to the role of equipment support and growth. The production of consumer goods manufacturing industry has improved significantly. The added value in the first quarter increased by 4.2% year-on-year, reversing the downturn since April 2022. The raw material manufacturing industry maintained steady growth. In the first quarter, the added value increased by 7.5% year-on-year, among which the growth rate of non-ferrous and chemical industries exceeded the overall industrial level.

　　Traditional tastes are sought after.

　　Our reporter Yu Jian

　　As the Mid-Autumn Festival approaches, there are more and more citizens and businessmen coming and going in the Mooncake Street in fengzhen city, Wulanchabu, Inner Mongolia. In addition to vehicles from local and surrounding cities, there are also many vehicles from Shanxi, Hebei, Shandong and even Beijing. The selection of plates, the purchase of boxes and the shipment of cars are the normal conditions for the sale of moon cakes here during this period.

　　Du Haizhen, head of fengzhen city Haifaxiang Food Co., Ltd., told reporters that this year’s mooncake business is good and the sales volume has also increased. "The merchants who purchase from the moon cake street are mostly in the surrounding areas such as Hubao’ e, and most of them choose traditional moon cakes, such as rock sugar, honey and red dates." Du Haizhen said.

　　Fengzhen city, which belongs to Wulanchabu City, is located in the south-central Inner Mongolia Autonomous Region, bordering Hebei Province and Shanxi Province, and is the foothold of many merchants. Fengzhen moon cakes originated in Longsheng Village, an ancient town. The high heat brought by the mixing of oil, sugar and flour, combined with the characteristics of long-term storage in a cool and dry environment, makes it a necessary dry food for travelers who travel long distances on the ancient tea-horse road to satisfy their hunger, and the name of Fengzhen moon cake is also widely circulated in the northern region.

　　Liu Wenjun, a resident of Fengzhen, is not only busy buying moon cakes for his family these two days, but also buying moon cake gift boxes for relatives and friends from other places. "According to our custom here, on the night of Mid-Autumn Festival, Yue Bai ceremony will be held at home. Buy some moon cakes and fruits, put a table on the balcony and worship the moon. " Liu Wenjun told reporters that there are many more varieties of moon cakes in Fengzhen than in the past, and everyone has more choices. "Older people like traditional tastes, and children prefer new varieties."

　　In recent years, fengzhen city has expanded the scope of brand promotion and expanded the domestic and foreign markets by organizing moon cake cultural festivals, online marketing, participating in exhibitions and other forms, and the popularity and reputation of Fengzhen moon cakes have been continuously improved. In 2015, Fengzhen Mooncake was awarded the National Geographical Indication Certification Trademark. In 2017, Fengzhen Mooncake was awarded the title of "Top Ten Famous Snacks in China" by China Cuisine Association. At the 6th Moon Cake (Food) Culture Festival in fengzhen city, which opened on July 30th this year, the sales of moon cakes in Fengzhen reached more than 6 million yuan in just five days.

　　During this period, Fengzhen moon cakes were also selling well in Haipeng Dim Sum Shop in wanda plaza, Jining District, Wulanchabu City. Wang Zhichao, a baker, said that this year’s Mid-Autumn Festival sales season came earlier than in the past, and people began to take action at the end of August. "In addition to making moon cakes, we also make all kinds of cakes here. During this time, cakes were basically not produced, and mooncakes were the main products, which sold very well, with daily sales reaching 10,000 yuan, especially the newly developed beef jerky mooncakes were very popular. "

　　Tommy, a citizen of Jining, is a post-90s generation. For her, mooncakes are not only consumed in the Mid-Autumn Festival, but when she doesn’t want to cook in the morning, Fengzhen mooncakes with a bowl of milk tea is a good breakfast and can also be used as a midnight snack at night. "Fengzhen moon cakes are affordable and convenient to buy, and have become an indispensable part of people’s lives."

　　There are many enterprises making moon cakes in Jining District, and Jiashi Food Co., Ltd. is one of them. "Although the moon cakes we make cannot be officially called ‘ Fengzhen moon cake ’ However, the production process is similar, and they all belong to mixed sugar moon cakes. Traditionally, there is no stuffing, and the main materials are oil, sugar and noodles. For more than 30 years, everyone is more recognized. " Li Xiaobo, the person in charge of the company, said that although the cost of raw materials for making moon cakes has risen recently, the company still insists that the price of moon cakes will not rise.

　　For Li Qiang, general manager of Inner Mongolia Enbao Food Co., Ltd., the pressure of mooncake sales this year is greater than in previous years. "It is still because the market competition is more intense." In Li Qiang’s view, understanding consumer demand is an important way to attract more consumers’ attention. "From the consumer feedback we have, we know that some foreign consumers can’t accept the taste of flaxseed oil in traditional Fengzhen moon cakes, so we have developed new varieties of moon cakes such as cheese drawing." Li Qiang said.

　　At present, there are more than 200 large and small moon cake production and sales enterprises in Wulanchabu, 2 enterprises above designated size and 14 enterprises settled in the moon cake production industrial park. In recent years, the average annual sales volume of moon cakes in Fengzhen is about 150 million to 200 million. The main markets are concentrated in the central and western Inner Mongolia, northwestern Shanxi, Beijing and other places, with an annual sales volume of about 500 million yuan, which has formed a certain industrial base.

　　Wei Zhong, chairman of fengzhen city Haipeng Food Co., Ltd. and president of fengzhen city Mooncake Industry Association, said that in recent years, the categories of mooncakes in Fengzhen are increasing, the sales methods are more yuan, the sales cycle is longer, and the industry has a good development momentum. "In addition to being a seasonal food for the Mid-Autumn Festival, Fengzhen moon cakes have also begun to be sold as a gift, becoming a characteristic business card representing Fengzhen and even Wulanchabu." However, Wei Zhong also said that problems such as insufficient innovation, serious homogenization competition and fierce price war still exist in the industry, and the sales scope of mooncakes is also limited. "I hope that all parties can work together to promote the healthy and orderly development of the moon cake industry in Fengzhen."

　　The reporter learned from the Wulanchabu Municipal Bureau of Commerce that Wulanchabu will take the mooncake production and sales enterprises authorized by the "original Wulanchabu" regional public brand as the starting point, further increase publicity and promotion, broaden the mooncake sales channels, and polish the golden signboard of "Fengzhen Mooncake". At the same time, relying on relevant industry associations, guide enterprises to increase investment in research and development, enrich product categories, and meet the consumption needs of different consumer groups.

　　A wide variety of styles make people love.

　　Our reporter Liu Cheng

　　"This year’s moon cakes have too many flavors, and they are all eye-catching!" In front of the moon cake shelves of Liqun Supermarket in Changjiang Road, West Coast New District of Qingdao, Liu Xue, a citizen of the new district, was full of harvest, carrying all kinds of moon cake gift boxes in his hands.

　　With the Mid-Autumn Festival approaching, mooncakes have also entered the peak season of sales. The reporter visited a number of supermarkets in the West Coast New District of Qingdao and found that each family has set up a mooncake area. Cartoon signs such as "Jade Rabbit" and "Full Moon" are placed next to the shelves, and there is a strong Mid-Autumn Festival atmosphere everywhere. In the mooncake sales area, merchants are even more ingenious. They not only launched mooncakes with various flavors for different consumer groups, but also launched their own specialty flagship products, which made sufficient supply preparations for citizens’ Mid-Autumn Festival consumption.

　　When you walk into Liqun Supermarket on Changjiang Road, you will see the mooncake shelf area directly. Royal Mobil, Daoxiang Village, Guangzhou Restaurant … … Moon cakes from different brands all over the country are neatly placed on four shelves, and the shelves are surrounded by customers who come to buy moon cakes. "We are confident in the influence of traditional festivals. This year, the price of gift box moon cakes is mainly concentrated in 200 yuan, and the customer demand is great. The sales of moon cakes are expected to exceed 600,000 yuan, a year-on-year increase of about 10%. " Petra Kwok, sales manager of Liqun Supermarket on Changjiang Road, pointed to the mooncake gift box nearby.

　　In addition to various brands, this year’s mooncake tastes are also "advancing with the times" and rich and diverse. On the basis of traditional Cantonese-style mooncakes and Soviet-style mooncakes, the merchants have also introduced trendy mooncakes such as semi-cooked cheese, French strawberries and durian with ice skin, and zero sucrose mooncakes for the elderly. "Bulk is a new flavor of moon cakes, buy back and want to try it yourself. The gift box can be used to visit relatives and friends, and it is well designed. " Liu Xuebian said while selecting moon cakes.

　　Also eye-catching, there is the "three pounds of big moon cakes" launched by Qingdao Shengkelong Shopping Plaza, a veteran local enterprise in the new district. When I came to Shengkelong’s processing factory, the reporter saw that with the roar of the machine running, the pastry chefs orderly poured white bean paste, flour, raisins, rose petal sauce, pumpkin kernels, sesame seeds and other ingredients into the blender to make fillings, and then completed the production and baking of the cake crust one after another, and finished the production of one big moon cake with full color and fragrance. “‘ Three catties of moon cakes ’ It is our first product in the local area, and its output accounts for about 60% of all our moon cake series, and it can sell nearly 10,000 pieces every year on average. " Wang Xiaokun, manager of Qingdao Shengkelong Food Co., Ltd. said.

　　Walking out of the factory, the reporter went to Renmin Road Store in Shengkelong Shopping Plaza. The front of the moon cake goods area is crowded, and many customers come here because of the "three pounds of moon cakes". "The meaning of the big moon cake is particularly good, symbolizing that the family is round and round, and the old people at home deliberately want to buy this!" Xue Li, a citizen of the new district, bought 10 boxes. She said that she would buy "three pounds of big moon cakes" every year for her relatives and friends in her hometown to taste.

　　According to Yang Zongli, manager of Renmin Road Store in Shengkelong Shopping Plaza, before and after the Mid-Autumn Festival, only one of their stores can sell more than 1,000 "three pounds of big moon cakes". Shengkelong Shopping Plaza has also opened online sales channels, and moon cakes can be sold as far as the three northeastern provinces and Hainan. In the packaging of moon cakes, Shengkelong strictly implements the latest national standards to control costs, simplify the complexity and ensure exquisiteness.

　　With the increasingly rational consumption in Mid-Autumn Festival, DIY moon cakes are also favored by the general public.

　　In the DIY moon cake classroom of Qingdao Angel Aroma Food Company, there is a cheerful atmosphere of Mid-Autumn Festival reunion, and many parents are taking their children to make "exclusive" moon cakes under the guidance of bakers — — Some use Taoshanpi as cake crust, and add hawthorn powder and matcha powder to make it appear in different colors; Some are busy filling with red bean paste, golden leg black truffle, salted egg yolk and other ingredients; Some are still struggling whether to use a blessing bag or a mold in the shape of a small animal … … "The moon in the Mid-Autumn Festival is particularly round, and Chang ‘e and Yutu live on it, so I chose the moon cake in the shape of a rabbit." Wang Haonan, a first-grade child who followed his parents to experience DIY moon cakes, showed the "rabbit" moon cakes in his hand.

　　"The original intention of our mooncake class is to let customers not only buy delicious mooncakes, but also make mooncakes symbolizing reunion by themselves. Many customers may not have been exposed to DIY moon cakes before. Making moon cakes by hand can give them a sense of freshness and accomplishment. It is also meaningful to give them to their families as gifts, so that they can spend a different Mid-Autumn Festival. " Zhuang Jing, founder of Qingdao Angel Aroma Food Company, said.

1905 movie network news A criminal police film starring Louis Koo, producer Tung shing Yee, screenwriter and director Feng Zhiqiang, and starring Zhang Jicong, Jessica Hester Hsuan, Yan Zhuoling, Jiang Haowen, Ar Fi, Tan Yaowen, An Zhijie, Ling Wenlong and Li Canchen will be released nationwide on October 12th.

On October 8th, Louis Koo and Jessica Hester Hsuan visited major companies successively, offering the first wave of post-holiday benefits to the reworked employees. The appearance of Louis Koo and Jessica Hester Hsuan in the same frame made everyone exclaim: See you for a long time! In the face of enthusiastic fans, Louis Koo showed his nature of "cosseting a warm man with powder" to the fullest, and kept pulling employees to take photos.

Louis Koo Jessica Hester Hsuan was "happy candy" by fans to guide employees to take photos and perform a memory killing.

Louis Koo and Jessica Hester Hsuan, who experienced "sweeping the building" for the first time, were in high spirits, and every appearance caused the employees to scream wildly. Facing enthusiastic fans, Louis Koo and Jessica Hester Hsuan distributed milk tea and desserts around the movie to bring "the best welfare" after the festival. In the face of the screen couple, the on-site staff also found out the classic stills of "Pet Love" in the past, hoping that the two of them would restore their shapes. The quick-witted Gu Zi immediately pulled two employees and said, "Come and set it."

In addition to releasing the online news of the movie "Crime Scene", Gu Xuan and his wife also experienced the work of a programmer. Facing the staff who were doing the explanation seriously, Gu Xuan and his wife were absorbed in it, and finally they personally designed and filmed a special little video. Subsequently, the staff said that they had just got married and sent wedding candy to Gu Xuan, who had been in powder for many years, which caused quite a stir for a time. In addition, Louis Koo and Jessica Hester Hsuan, incarnated as HR, also called the new graduates who passed the school recruitment and personally delivered the Offer. This unique Offer was enough for this employee to remember.

Louis Koo: "Playing" Jessica Hester Hsuan is the most profound scene. Louis Koo gave Xuanxuan a security clearance.

In the following activities, Louis Koo, who couldn’t bear the fact that everyone was too tired, personally took the mobile phone of the on-site staff to start the selfie mode, and then kept signing autographs for everyone. The employees who got this "exclusive benefit" could not hide their excitement and said "fortunately, they came to work today". Facing the interview, Louis Koo joked with the host from time to time, but when the host asked about the most impressive scene in the movie "Crime Scene", Gu Xuan said almost at the same time that "Jessica Hester Hsuan (I) was beaten".

"You don’t know how hard he works," Jessica Hester Hsuan quipped. In an interview with an entertainment platform, Gu Xuan and his wife did not forget to "support each other". Jessica Hester Hsuan said, "As long as Gu Zi is looking for my movie, I will shoot it." Facing the excited employees, Louis Koo also worked as a security guard for Jessica Hester Hsuan, pretending to be "fierce" and experiencing the "clearing" work.

The movie Crime Scene tells the story of Wang Xinyuan (Louis Koo), a ruthless criminal gang leader, and his accomplices who caused many casualties in a jewelry store robbery. Two months later, his accomplice was murdered by someone cutting his throat and died in the house. The police listed Wang Xinyuan as the number one suspect on the grounds that the spoils were unevenly divided into infighting. With the in-depth investigation of the young police officer Lin Faliang (Zhang Jicong), it is not easy to find out the truth of the case.

1905 movie network news A few days ago, the cover pictorial of the March issue was filmed for Esquire Korea. The whole group of pictorial was immersed in a cold and gray atmosphere, and the retro film sense filled the atmosphere. Lee Jong Suk performed several sets of leisure suit, windbreaker or mix-and-match shapes, and the tall figure relaxed the sense of fashion.

In an interview with Esquire Korea, he was asked whether his girlfriend IU became a pillar in his low tide. He generously said that the existence of his girlfriend was a force that he could rely on with peace of mind, especially in the stage of entering the 1930s, and he got a lot of comfort from his conversation with IU.Lee Jong Suk also said that his girlfriend IU brought him not only happiness, but also the idea of "wanting to be more mature" rose in his heart whenever the other person praised "you have become more mature", and because of IU, "I want to be a better person than now".

The overall infection rate of HP in the tested population is 30%, including 32.7% for adults and 11.4% for children … Recently, Jiangsu released the "Helicobacter pylori infection and drug resistance map" for the first time.

The infection map shows that the infection rates in Changzhou, Zhenjiang, Taizhou, Xuzhou, Suzhou, Nantong, Nanjing and Yangzhou are all higher than the overall infection rate in Jiangsu Province, with Changzhou being the highest, accounting for 42.9%. The infection rates of 13 prefecture-level cities are shown in the following figure:

2023 Edition of Helicobacter Pylori Infection Map in Jiangsu Province

Helicobacter pylori will live in the epithelium of gastric mucosa, and the urease it secretes can affect the secretion of gastric acid and destroy the barrier of gastric mucosa, which is also one of the important causes of chronic gastric disease, gastric or duodenal ulcer and even gastric cancer. The number of people infected with Helicobacter pylori in China is very high. In recent years, with the promotion of health science popularization, people’s understanding of Helicobacter pylori has gradually deepened.

What is Helicobacter pylori?

Helicobacter pylori is a kind of bacteria. After entering the human body from the oral cavity, it is fixed in the stomach, which can cause a variety of diseases in and out of the stomach. After fixed, it is difficult for the body to remove it spontaneously, resulting in lasting or lifelong infection. In 1994, Helicobacter pylori was listed as a class I carcinogen of human gastric cancer by the World Health Organization (WHO) and the International Agency for Research on Cancer (IARC). In 2022, the United States Department of Health and Human Services listed Helicobacter pylori as a clear carcinogen.

Helicobacter pylori infection is the main risk factor of gastric cancer, which can significantly increase the risk of gastric cancer (3-6 times), and eradication of Helicobacter pylori can reduce the risk of gastric cancer by 54%, which plays a clear etiological role.

How about infectivity?

Helicobacter pylori infection is an infectious disease that can spread from person to person, especially among family members.

Helicobacter pylori infection is a global problem, and the global infection rate has exceeded 50%. A recent screening result shows that the personal infection rate in China is about 40%, and the family infection rate is about 70%. The infection rate increases with age.

People are generally susceptible to Helicobacter pylori. Including people with low education, high family density, low income, eating out more and poor hygiene habits.

It has been pointed out that children are susceptible to Helicobacter pylori, and the infection within the family mainly occurs before the age of 12. Both parents were infected with Helicobacter pylori, and the infection rate of their children was 69.34%. This also suggests that adults in families with children should pay special attention to the detection of HP, find that infection should be actively eradicated, pay attention to not sharing tableware in life, and do not chew and feed infants to avoid HP infection in the family.

75% of adult infected people carry "virulent strains"

In the whole province, 75.6% of HP strains were infected by adults, and 60.5% were infected by children.

Helicobacter pylori strains with certain virulence factors can help them colonize human stomach and survive for a long time, and even induce intestinal differentiation and intestinal metaplasia, leading to the irreversible stage of cancer. There are a large number of virulent strains in the province, which should be paid more attention to. After personal infection, we should cooperate with doctors to actively carry out eradication treatment.

What are the symptoms after infection?

Helicobacter pylori infection sometimes has no obvious symptoms. Symptoms can be manifested as bad breath, belching, loss of appetite, fullness, discomfort in the upper and middle abdomen, dull pain, and even symptoms of acid reflux, nausea and vomiting.

What diseases are they related to?

In the digestive system, Helicobacter pylori infection is an important pathogenic factor of chronic active gastritis, peptic ulcer, gastric mucosa-associated lymphoid tissue (MALT) lymphoma and gastric cancer. Especially in patients with peptic ulcer, the infection rate of Helicobacter pylori is extremely high. Eradication of Helicobacter pylori can promote ulcer healing and significantly reduce the recurrence rate of ulcer.

In addition, Helicobacter pylori is also related to some non-digestive diseases. Helicobacter pylori infection in the blood system is related to unexplained iron deficiency anemia, primary immune thrombocytopenia, vitamin B12 deficiency and other diseases. For patients with these diseases, Helicobacter pylori should be detected and eradicated. With regard to the manifestations of nervous system, more and more studies have linked this bacterium with multiple sclerosis, Alzheimer’s disease, Parkinson’s disease and Guillain-Barre syndrome. Interestingly, the risk of cardiovascular diseases such as atherosclerosis is also affected by infection.

How to prevent it every day?

Helicobacter pylori is particularly prone to family cluster infection, so it is necessary to mobilize the whole family to prevent it and treat it at the same time if necessary. Disinfection of bowls and chopsticks, sharing meals, paying attention to oral hygiene, changing toothbrushes regularly and exercising more to enhance immunity are the most critical measures to prevent this bacterial infection. If the tableware is recycled and not disinfected in time, it may also infect Helicobacter pylori. In addition, parents and children’s tableware should be used separately, and the habit of feeding infants or giving chewed food to children should be abandoned. Patients after radical treatment should also pay attention to prevent reinfection, mainly to prevent reinfection through daily intimate contact.

Which groups of people suggest checking?

First of all, people and their families who have been confirmed to have stomach diseases such as gastric ulcer, chronic gastritis and gastric cancer; Secondly, people who feel abdominal distension, abdominal pain, nausea and other digestive tract discomfort symptoms; The latest research recommends that the family members of patients with Helicobacter pylori positive should also be tested for Helicobacter pylori.

The two antibiotics are highly resistant.

According to experts, we usually talk about the drug resistance of Helicobacter pylori, which tests the sensitivity of the strains carried by infected people to antibiotics.

Jiangsu "drug resistance map" shows that the resistance rate of adults and children to clarithromycin is over 50%, of which the resistance rate of adults to clarithromycin is 51.9% and that of children to clarithromycin is 55.8%. This result is obviously higher than the drug resistance reported in the current literature. According to "Systematic Review and Meta-analysis of Primary Antibiotic Resistance of Helicobacter pylori in China", the drug resistance rate of clarithromycin reached 34% from 2016 to 2020.

Jiangsu "drug resistance map" also shows that the drug resistance rate of adults to levofloxacin is nearly 40%, and that of children to levofloxacin is 23.3%. The resistance rate of adults to furazolidone is 10%, and that of children is 4.7%. The two populations were basically not resistant to amoxicillin and tetracycline.

2023 Edition of the "Drug Resistance Map" of Helicobacter pylori in Jiangsu Province

According to the "Urban Drug Resistance Map" released by Jiangsu Province, the drug resistance of Helicobacter pylori in 13 districts and cities in Jiangsu Province is different.

Huai ‘an City has the highest drug resistance rate of levofloxacin among 13 districts and cities, with a drug resistance rate of 66.7%. The resistance rate of clarithromycin in Yangzhou was the highest, accounting for 69.6%. Yancheng is the city with the highest drug resistance rates of amoxicillin and furazolidone, which are 2.3% and 20.9% respectively.

The difference of drug resistance in different cities suggests that each region or even everyone is infected with different strains of Helicobacter pylori, and there are also differences in individual medication history and local medication habits. Therefore, when HP infected people receive eradication treatment, if they can obtain the individual drug resistance of Helicobacter pylori, choose sensitive antibiotics and avoid antibiotics with known drug resistance, theoretically, the success rate of the first eradication can be greatly improved.

Professor Wang Qizhi, chairman of the Gastroenterology Branch of Anhui Medical Association, pointed out that it is very important to know the antibiotic resistance in the eradication of Helicobacter pylori. The drug resistance and corresponding treatment are different in different regions. With empirical treatment, the eradication effect will be different. Drug resistance is also the main obstacle to the prevention and control of this disease.

Which groups of people suggest eradication? What about the treatment plan?

Family members infected with Helicobacter pylori are always potential sources of infection and have the possibility of continuous transmission to other family members, but whether they are infected or not is related to the intimacy of contact and genetic background. All adults infected with Helicobacter pylori in the family should consider eradication treatment. Especially those who are over 35 years old, have a family history of gastric cancer and a history of gastropathy. According to the risk assessment, children with peptic ulcer and gastric MALT lymphoma can consider eradication treatment, and children with chronic gastritis, family history of gastric cancer, unexplained refractory iron deficiency anemia, long-term NSAID (including low-dose aspirin), guardians or elderly children (12-14 years old) who strongly demand treatment can also consider eradication. For the elderly people infected with Helicobacter pylori in the family, they often suffer from a variety of other systemic diseases at the same time, and the combined medication is complicated. Therefore, before eradication treatment, we should evaluate the risks and benefits and choose an individualized and standardized treatment plan. At present, the commonly used treatment for eradicating Helicobacter pylori in China is bismuth-containing quadruple therapy, that is, a proton pump inhibitor (PPI)+ bismuth+two antibiotics. Because Helicobacter pylori is easily resistant to antibiotics, it is very important to choose the first treatment plan. It is suggested that you must go to the gastroenterology department of a regular hospital for treatment. After the eradication of Helicobacter pylori, C13 and C14 breath tests were performed again one month after drug withdrawal to evaluate the curative effect, and gastroscopy should be performed if necessary.

　　Xinhua News Agency, Tianjin, November 24th (Reporter Yin Siyuan, Zhang Jianxin) There are high incidence of respiratory infections in winter, and some children have typical symptoms of respiratory infections such as fever, sore throat and cough. Monitoring data show that mycoplasma pneumoniae infection and influenza virus infection are the main types of patients currently in hospital. How to distinguish mycoplasma pneumoniae infection from influenza virus infection? Is self-medication feasible? Under what circumstances do you need to see a doctor? The reporter interviewed relevant experts to answer questions.

　　Li Yuechuan, director of the Department of Respiratory and Critical Care Medicine of Tianjin Chest Hospital, said that mycoplasma is a pathogenic microorganism, smaller than bacteria and larger than viruses. Mycoplasma pneumoniae is one of the subtypes, which mainly invades the respiratory system and then causes infection, accompanied by fever, cough and other symptoms. How to distinguish mycoplasma pneumoniae infection from influenza? Li Yuechuan said that in terms of symptoms, the fever caused by mycoplasma pneumoniae infection is generally more than 38 C. If there is a high fever above 39 C, it is highly likely to be influenza A; In terms of headache symptoms, the headache caused by mycoplasma infection is often severe, and the severe headache caused by influenza A is less; Cough symptoms caused by mycoplasma and influenza virus are also different. Cough caused by influenza A is generally not severe, while mycoplasma pneumoniae infection is more likely to cause severe cough symptoms. In addition, mycoplasma infection may also cause rash, meningitis, hemolysis and other symptoms in children.

　　After the child has symptoms such as fever and cough, some parents choose to give their children azithromycin and other drugs. In view of this phenomenon, Xu Yongsheng, director and chief physician of the Respiratory Department of Tianjin Children’s Hospital, said that azithromycin has a good effect on the treatment of mycoplasma pneumoniae infection, but it is not necessarily the best choice for other pathogens. "The use of azithromycin depends on age and basic state, and not all children can use it. Therefore, it is not advisable to take antibacterial drugs blindly. " Xu Yongsheng said.

　　On November 22nd, in Tianjin Children’s Hospital, many parents brought their children to see a doctor. (Photo courtesy of the interviewee)

　　Under what circumstances does the child need to go to the hospital? Xu Yongsheng said that for most children, respiratory tract infection is self-limited, and the symptoms are often the external manifestations of the body’s struggle with pathogens. With more rest and more water, most children can overcome pathogens. However, if the following situations occur, it is necessary to seek medical attention in time: First, the condition of children in the younger group changes rapidly and the symptoms are atypical, so parents often find it difficult to identify critical situations and need to seek medical attention as soon as possible; Second, it is necessary to assess the child’s mental state. If there are symptoms such as listlessness, less communication and interaction, and indifference, you need to go to the hospital in time; Third, when the symptoms are not relieved after a long course of disease, you need to go to the hospital for further diagnosis and treatment.

　　How should students guard against it? Dong Xiaochun, chief physician of the Center for Infectious Diseases Prevention and Control of Tianjin Center for Disease Control and Prevention, said that students should develop good personal hygiene habits, cover their nose and mouth when coughing or sneezing, and pay attention to hand hygiene; Report to teachers and parents immediately when you feel unwell, so as to avoid attending classes with illness; Wear a mask when going out to reduce activities in crowded places; When parents find that their children have fever, cough and other related symptoms, they should seek medical treatment in time.

CCTV News:With regard to the operation of China’s economy, many international financial institutions said that in the first quarter of this year, China’s macroeconomic development showed many bright spots, including the rebound in consumption, steady investment in service industry and infrastructure, and foreign trade growth exceeding expectations. Among them, the wholly-owned company established by Fitch Ratings in China — — Tang Daqian, an analyst at Fitch Bohua, pointed out that consumption plays a significant role in boosting China’s economy.

Tang Daqian, Deputy Director of Huiyu Bohua Industrial and Commercial Enterprise Department:With the expansion of consumption radius and richer consumption scenarios, this directly beneficial service industry may recover more vigorously. We are optimistic about China’s economic growth in the first quarter of 2023, including the whole year. We believe that China’s economic growth is resilient.

Looking forward to the whole year of 2023, analysts predict that China’s economic growth will continue to maintain a "steady to good" trend in the future and lead the world.

Xing Ziqiang, Chief Economist of Morgan Stanley China:We judge that after a strong recovery in the first quarter, China’s economic growth (speed) is expected to reach 5.7% this year, contributing more than 40% to the global economic growth, and China and Asia have outperformed and led the world.

　　In order to promote consumption and promote the popularization of green and energy-saving household appliances, Jiangsu Province has implemented a series of state subsidy policies. These policies not only cover traditional household appliances, but also extend to 3C digital products such as smart phones. This paper will introduce in detail the operation process of Jiangsu’s national subsidy policy in 2024, especially how to receive mobile phone subsidies to help consumers better understand and enjoy this preferential policy.

　　First, the operation process of Jiangsu state subsidy policy in 2024

　　1. Scope and standard of subsidies

　　Jiangsu’s state subsidy policy mainly aims at qualified individual consumers, and provides financial subsidies when purchasing designated household appliances and 3C digital products. The subsidy is applicable from September 7, 2024 to December 31, 2024. The household appliances covered by the policy include eight traditional categories (such as televisions, refrigerators, washing machines, etc.), as well as a variety of additional household appliances and smart household appliances (projectors) in Jiangsu Province. In addition, 3C digital products, such as mobile phones, tablet computers, wireless Bluetooth headsets, etc., are specially included.

　　2. Operation process of state subsidy policy

　　Note that Jiangsu household appliances subsidies do not need to be specially collected (but the receiving address is only available in Jiangsu Province). Select the appliances you want to buy (participate in household appliances subsidies) and the order will be fully reduced automatically.

　　Step one:Download and register CCB Life APP.

　　Consumers first need to download the "CCB Life" APP in the app store and complete the registration. During the registration process, you need to enter the mobile phone verification code, set the password, and carry out real-name authentication. After real-name authentication, open the wallet and bind the bank card to support debit cards or credit cards of major banks.

　　Step two:Open JD.COM APP and enter "projector state subsidy" in the search bar to enter the "Digital State subsidy page". This page lists all regions participating in the national subsidy policy. Taking Jiangsu Province as an example, users can click "Jiangsu Province" to enter the corresponding area;

　　Step two:Then click the link "Click into the Zone without qualification" on the page, and select "Projector" from the classification;

　　Step 3:Users can choose their favorite projector model and enter the product details page. There will be a logo of "State Subsidy" on the page. When making purchase and payment, please pay attention to confirm that the receiving address is set to Jiangsu Province and selectChina construction bank life APPPay to enjoy the subsidy policy.

　　Precautions:

　　1. Jiangsu subsidy policy is open to national IP addresses, but the receiving address needs to be in Jiangsu Province;

　　2. Each consumer can only enjoy one subsidy for each product, and the subsidy amount is limited;

　　3. Please carefully check the product information, subsidy policy and return rules before purchasing;

　　4. If you have any questions about the subsidy collection, you can consult the customer service of Dangbei Store;

　　5. The national subsidy policy may change in real time, so it is recommended to get early and enjoy preferential treatment.

　　Second, Jiangsu Guobu mobile phone subsidy process

　　Step 1: Confirm the subsidy qualification.

　　Through the "CCB Life" APP, enter the "Suxin Consumption Green Energy-saving Home Appliances Trade-in Special Activity" area. Customers who participate in the activity for the first time need to complete the real-name authentication and register first. After successful registration, they can apply for the eight categories of household appliances subsidies designated by the state with one click on the activity page. For the increased household appliances and 3C digital products in Jiangsu Province, there is no need to apply for subsidy qualification separately.

　　Step 2: Buy subsidized products.

　　After the application for subsidy qualification is completed, consumers can go to offline stores or online sales enterprises participating in the activities to purchase goods within the scope of subsidies. For 3C digital products such as mobile phones, consumers can find and select the style they want to buy on the APP and confirm the subsidy amount.

　　Step 3: Complete the payment

　　After the purchase is completed, consumers can complete the payment in stores or online platforms. When paying offline, the store staff will confirm the subsidy qualification and place an order in advance, and the consumer will check the order to be paid in the APP and complete the payment. When making online payment, the consumer clicks "Su Xin Consumption-CCB Life" when placing an order for payment, guiding to jump to the APP to complete the payment, and returning to the online sales enterprise to confirm the payment result.

　　Step 4: Pay and enjoy the subsidy.

　　In the payment process, the system will automatically calculate the subsidy amount, and consumers only need to pay the amount after deducting the subsidy. After the payment is successful, consumers can choose to pick it up at the store or deliver it home.

　　Precautions:

　　For 3C digital products, the subsidy is also based on 15% of the discounted price of the enterprise, and each person is limited to one product of each type, with the subsidy ceiling of 1,500 yuan. 3C digital product subsidies are limited to offline stores.When buying mobile phones, tablets and other electronic products that are easy to realize, it is necessary to unpack and activate them on site.Stores should keep clear activation photos including SN code, IMEI code, package SN code, shopping receipt or personal ordinary invoice (indicating the machine model) and activation date to ensure that all information is consistent.

　　Third, the new area collection process:

　　1.2024 government home appliance subsidy projector inventory! Zhejiang/Guangdong/Fujian/Sichuan and many other places can get it.

　　2. How to use government subsidies for trade-in in Hubei? Hubei trade-in subsidy collection method

　　3.2024 How to get the old-for-new subsidy in Guangdong? Guangdong Trade-in Subsidy Collection Course

　　4. How does Zhejiang Province use home appliance subsidies to purchase projection? Tutorial for Replenishment of Dangbei Projection Country in 2024

　　5. How does Dangbei Projection in Sichuan Province receive the government renewal subsidy? Detailed course of actual measurement

This article is transferred from "Xin Zhixun"

On September 19th this year, Huawei officially released the annual flagship Mate 30 and Mate 30 Pro in Munich, Germany, and also announced the 5G version of Mate 30 series equipped with Kirin 990 5G chip. However, it was not until November 1st, more than a month after the launch of the 4G version of Mate30 series, that the 5G version of Huawei Mate 30 series, which was priced at 4999 yuan, was finally put on sale, and the sales in Huawei’s official mall exceeded 700 million in seven minutes.

Recently, TechInsights, a foreign professional analysis organization, conducted an in-depth disassembly analysis of Mate30 Pro 5G version (version of 8GB RAM+256GB ROM), which not only analyzed the main components on the motherboard of Mate30 Pro 5G version, but also included the disassembly analysis of Kirin 990 5G processor.

Let’s take a look at it:

According to TechInsights’ analysis of the motherboard of Mate30 Pro 5G,

Look at the front of the motherboard first. As indicated in the above figure, the components from left to right are:

Haisi Hi6421 power management IC

Haisi Hi6422 power management IC

Haisi Hi6422 power management IC

Haisi Hi6422 power management IC

Nxp PN80T secure NFC module

STMicroelectronics (stmicroelectronics) BWL68 Wireless Charging Receiver IC

Halo Micro (Guangdong Xidi Microelectronics) HL1506 Battery Management IC

Look at the back of the motherboard first. As indicated in the above figure, the components from left to right are:

Halo Micro (Guangdong Xidi Microelectronics) HL1506 Battery Management IC

Haisi Hi6405 audio codec

STMP03 (unknown)

Silicon Mitus SM3010 power management IC (possible)

Cirrus Logic CS35L36A audio amplifier

Lianfa technology MT6303 envelope tracker IC

Haisi Hi656211 power management IC

Haisi Hi6H11 LNA/RF switch

Murata front-end module

Haisi Hi6D22 front-end module

HiSilicon Kirin 990 5G SoC and SK Hynix H9HKNNNFBMAU-DRNEH 8GB Mobile LPDDR4X SDRAM with PoP package.

Samsung KLUEG8UHDB-C2D1 256GB UFS storage

Texas Instruments TS5MP646 MIPI switch

Texas Instruments TS5MP646 MIPI switch

Haisi Hi1103 Wi-Fi/BT/GNSS wireless integrated IC

Haisi Hi6H12 LNA/RF switch

Haisi Hi6H12 LNA/RF switch

Cirrus Logic CS35L36A audio amplifier

Haisi Hi6D03 MB/HB power amplifier module

After introducing the motherboard, let’s take a look at another sub-version:

As indicated in the above figure, from left to right are:

Haisi Hi6365 RF transceiver

Unknown 429 power amplifier (possible)

Haisi Hi6H12 LNA/RF switch

Qualcomm QDM2305 front-end module

Haisi Hi6H11 LNA/RF switch

Haisi Hi6H12 LNA/RF switch

Haisi Hi6D05 Power Amplifier Module

Murata front-end module

Unknown 429 power amplifier (possible)

Let’s take a look at the internal situation of Kirin 990 5G:

As mentioned before, Kirin 990 5G integrated Huawei’s Ba Long 5005G baseband chip into the SoC for the first time, which made it the world’s first commercial 5G SoC, and also supported the SA/NSA dual-mode and backwards compatibility 4G/3G/2G network. In contrast, at present, other commercial 5G mobile phones are basically implemented in the form of processor plug-in 5G baseband, which will further increase the cost and power consumption.

Kirin 990 5G adopts PoP package, and SK Hynix H9HKNNNFBMAU-DRNEH 8GB mobile LPDDR4X SDRAM is stacked on top of it, which is the same as what we saw in Huawei Mate 20 X(5G) before.

The chip size of Kirin 990 5G SoC is 10.68mm x 10.61mm = 113.31mm 2. In contrast, the chip size of Mate 20 X(5G) and Kirin 9804G AP+modems is 8.25mm x 9.16mm = 75.57mm2, while the chip size of Balong 5000, an independent 5G modem, is 9.82mm x 8.74mm = 85.83mm2. Kirin 980 4G AP/modem chip size+5G Balong modem chip size = 161.4mm2 The die size of Kirin 990 5G SoC is 113.31mm2, which is much smaller than the previous two-component solution, which may be benefited from TSMC’s latest 7nm FinFET EUV technology.

Comparison of chip sizes between Kirin 980 (left) and Kirin 990 5G (right)

Summary: From the main 36 components in Huawei Mate 30 Pro 5G version listed above, 18 of them are from Huawei HiSilicon’s self-developed chips, accounting for half of the total. Moreover, we can see that Huawei also introduced the battery management chip of Guangdong Xidi Microelectronics, a domestic chip manufacturer, and the envelope tracking chip of MediaTek in flagship machine for the first time. In addition, we can also see that the proportion of components from Japan, South Korea and Europe is also increasing. The front-end module of Murata in Japan, the silicon micro-power management IC in South Korea and the wireless charging chip of Legally Semiconductor in Europe all seem to enter Huawei’s flagship models for the first time.

Surprisingly, among the core components of Huawei Mate 30 Pro 5G version, there are still American devices, such as chips from Texas Instruments, and the RF front-end module of Qualcomm and the audio amplifier of Lingyunluo of the United States have appeared for the first time. At present, the United States has not lifted the ban on Huawei, and these American devices should have been stocked by Huawei before. However, compared with the previous internal main components of Mate 20 X 5G, the proportion of components from the United States is indeed further reduced. For example, instead of Qorvo and Skyworks front-end modules, there are more HiSilicon RF front-end devices and Murata front-end modules, and Meguiar’s DRAM has also been replaced by SKHynix’s.